25-Hydroxyvitamin D3

Name: 25-Hydroxyvitamin D3
Brand: YSBIOTECH
Availability: InStock
Rating: 5 (1 reviews)

Product Name:

CAS Number:

19356-17-3

Molecular Formula:

C27H44O2

Molecular Weight:

400.65

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Description
Efficacy
Specifications

25-hydroxyvitamin D₃ (abbreviated 25(OH)D₃), is a form of vitamin D produced in the liver by hydroxylation of vitamin D₃ (cholecalciferol) by the enzyme vitamin D 25-hydroxylase. 25(OH)D₃ can be further hydroxylated by the enzyme 25(OH)D-1α-hydroxylase, primarily in the kidney, to form calcitriol (1,25-(OH)₂D₃), which is the active hormonal form of vitamin D.

25-hydroxyvitamin D₃ is strongly bound in blood by the vitamin D-binding protein. Measurement of serum 25(OH)D₃ is the usual test performed to determine a person's vitamin D status, to show vitamin D deficiency or sufficiency. 25(OH)D₃is available as an oral medication in some countries to supplement vitamin D status

Efficient Absorption & Potency
Oral calcifediol is absorbed more efficiently than native vitamin D₃ (cholecalciferol).

- It raises serum 25(OH)D levels 2–5 times faster than the same dose of vitamin D₃.
Clinical Uses
- Vitamin D deficiency: More rapid correction compared to cholecalciferol, especially useful in patients with severe deficiency or urgent needs.
- Malabsorption syndromes: Since it bypasses liver hydroxylation, it works better in patients with impaired liver function, obesity, chronic kidney disease, or malabsorption (e.g., celiac disease, bariatric surgery).
- Bone health: Improves calcium and phosphate absorption, helping reduce risk of osteomalacia, rickets, osteoporosis, and fractures.
Immunomodulatory Effects
- Plays a role in regulating immune responses. Some studies suggest calcifediol supplementation may help reduce severity of respiratory infections, and it was studied during COVID-19 for potential benefits in reducing ICU admission risk.
Safety & Efficacy
- More predictable dose-response than cholecalciferol (less variability among individuals).
- Generally well tolerated, but excessive intake can cause hypercalcemia.

Tests	Limits	Methods
Appearance	White to light yellow powder	Visual
Mesh Size	90% pass 80 mesh	USP<786>
25-Hydroxyvitamin D3 Monohydrate content	≥1.25%	USP<621>
Loss on drying	≤5%	USP<731>
Lead (Pb)	≤10.0 ppm	USP<233>
Arsenic (As)	≤2 ppm	USP<233>
Aflatoxin B1	≤20.0 ppb	ISO 16050
Salmonella	Negative/25g	USP-NF<62>
Coliforms (MPN)	≤100 /g	USP-NF<62>
Packing: Packaged 25kg or 1kg packed with single-layer polyethylene bag as liner and seal-heated aluminum foil bags. Storage Condition: Keep away from direct light in a cool place, and sealed.

25-Hydroxyvitamin D3

Description

Efficacy

Specifications